Zentrum für Humangenetik und Laboratoriumsmedizin, Dr. Klein, Dr. Rost und Kollegen

Publikationen unserer Mitarbeiter aus dem Bereich Molekulargenetik

K. Mayer:
Möglichkeiten der Molekulargenetische Diagnostik beim Ehlers-Danlos Syndrom in: Was ist das Ehlers-Danlos Syndrom?
Deutsche Ehlers-Danlos Initiative (Herausgeber) September 2009

Faivre L, Collod-Beroud G, Callewaert B, Child A, Loeys BL, Binquet C, Gautier E, Arbustini E, Mayer K, Arslan-Kirchner M, Kiotsekoglou A, Comeglio P, Grasso M, Beroud C, Bonithon-Kopp C, Claustres M, Stheneur C, Bouchot O, Wolf JE, Robinson PN, Adès L, De Backer J, Coucke P, Francke U, De Paepe A, Boileau C, Jondeau G.
Pathogenic FBN1 mutations in 146 adults not meeting clinical diagnostic criteria for Marfan syndrome: further delineation of type 1 fibrillinopathies and focus on patients with an isolated major criterion.
Am J Med Genet A. 149A(5):54 (2009)

Faivre L, Masurel-Paulet A, Collod-Béroud G, Callewaert BL, Child AH, Stheneur C, Binquet C, Gautier E, Chevallier B, Huet F, Loeys BL, Arbustini E, Mayer K, Arslan-Kirchner M, Kiotsekoglou A, Comeglio P, Grasso M, Halliday DJ, Béroud C, Bonithon-Kopp C, Claustres M, Robinson PN, Adès L, De Backer J, Coucke P, Francke U, De Paepe A, Boileau C, Jondeau G.
Clinical and molecular study of 320 children with Marfan syndrome and related type I fibrillinopathies in a series of 1009 probands with pathogenic FBN1 mutations.
Pediatrics. 123(1): 391 (2009)

Faivre L, Collod-Beroud G, Callewaert B, Child A, Binquet C, Gautier E, Loeys BL, Arbustini E, Mayer K, Arslan-Kirchner M, Stheneur C, Kiotsekoglou A, Comeglio P, Marziliano N, Wolf JE, Bouchot O, Khau-Van-Kien P, Beroud C, Claustres M, Bonithon-Kopp C, Robinson PN, Adès L, De Backer J, Coucke P, Francke U, De Paepe A, Jondeau G, Boileau C.
Clinical and mutation-type analysis from an international series of 198 probands with a pathogenic FBN1 exons 24-32 mutation.
Eur J Hum Genet. 17(4):491 (2009)

Mayer K:
Indication criteria for disease: Tuberous sclerosis (TSC) [TSC1, TSC2].
Veröffentlicht in deutscher Sprache am 21.5.2008 auf
gfhev.de/de/leitlinien/Diagnostik_LL.htm
 und in englischer Sprache 2009

Frédéric MY, Monino C, Marschall C, Hamroun D, Faivre L, Jondeau G, Klein HG, Neumann L, Gautier E, Binquet C, Maslen C, Godfrey M, Gupta P, Milewicz D, Boileau C, Claustres M, Béroud C, Collod-Béroud G.
The FBN2 gene: new mutations, locus-specific database (Universal Mutation Database FBN2), and genotype-phenotype correlations.
Hum Mutat. 30(2):181 (2009)

Ashraf S, Hoskins BE, Chaib H, Hoefele J, Pasch A, Saisawat P, Trefz F, Hacker HW, Nuernberg G, Nuernberg P, Otto EA, Hildebrandt F.
Mapping of a new locus for congenital anomalies of the kidney and urinary tract on chromosome 8q24.
Nephrol Dial Transplant 25(5): 1496 (2009)

Klein HG, Funke K, Neumaier M, Langmann Th, Knabbe C, Cullen P.
Kriterien für den Einsatz von Einzelnukleotidpolymorphismen (SNPs) in der medizinischen Routinediagnostik: Erarbeitung technischer und diagnostischer Empfehlungen.
J Lab Med. 30:142 (2006)

R. Wienecke, I. Fackler, U. Linsenmaier, K. Mayer, T. Licht, M. Kretzler.
Antitumoral activity of rapamycin in renal angiomyolipoma associated with tuberous sclerosis complex.
Am J Kidney Dis. 48: 27 (2006)

H.-G. Klein, K. Mayer.
Molekulare Grundlagen der autosomal-dominanten polyzystischen Nierenerkrankung.
DADE BEHRING NEWS 1 (2006)

T Bohrer, H.-G. Klein, O. Elert.
Left ventricular non-compaction associated with a genetic variant of the CYP2C9 gene.
Heart Lung Circ. 15(4): 269 (2006)

F. Thiemann, P.M. Cullen, H.-G. Klein
Leitfaden Molekulare Diagnostik.
Wiley-VCH Verlag, Weinheim, (2006)

M. Nellist, O. Sancak, M.A. Goedbloed, C. Rohe, D. van Netten, K. Mayer, A. Tucker-Williams, A.M. van den Ouweland, D.J. Halley.
Distinct effects of single amino-acid changes to tuberin on the function of the tuberin-hamartin complex.
Eur J Hum Genet. 13: 59 (2005)

K. Mayer and C. Marschall.
Molekulargenetische Diagnostik von Bindegewebserkrankungen.
J Lab Med. 29: 176 (2005)

I. RostH.-G. Klein
Genetic testing for diseases associated with mental retardation.
J Lab Med. 29: 152 (2005)

R. Besch, C. Marschall, T. Schuh, C. Giovannangeli, C. Kammerbauer, K. Degitz.
Triple helix-mediated inhibition of gene expression is increased by PUVA.
J Invest Dermatol. 122: 1114 (2004)

H.-G. Klein, D. Gorinevski, J. HörmannC. MarschallK. Mayer, M. Vanetti.
Whole genome microarray analysis and target validation by qPCR.
J Lab Med. 28:215 (2004)

K. Mayer, M. Goedbloed, K. van Zijl, M. Nellist, H.-D. Rott.
Characterization of a novel TSC2 missense mutation in the GAP related domain associated with minimal clinical manifestations of tuberous sclerosis.
J. Med. Genet .  41:64 (2004)

J.R. Bogner, B. Lutz, H.-G. Klein, C. Pollerer, U. Troendle, F.-D. Goebel.
Association of highly active antiretroviral therapy failure with chemokine receptor 5 wild type.
HIV Med. 5:264 (2004)

T.Siegert, H.-G. KleinC. Marschall, H. Schmidt.
Osteogenesis imperfecta Typ I: Fallbericht mit bis dato nicht beschriebener Mutation im COL1A1-Gen.
Klin Pädiatr. 216:91 (2004)

K. Mayer.
Application of the protein truncation test (PTT) for the detection of tuberous sclerosis complex type 1 and 2 (TSC1 and TSC2) mutations.
Methods Mol Biol. 217: 329 (2003)

H.-G. Klein, J. Rauch, B. Busse, U. Grau, C. Marschall.
Single Nucleotide Polymorphisms in der medizinischen Prädispositionsdiagnostik.
Frauenarzt 44:30 (2003)

C. Marschall.
Molekularbiologie und Genetik des Alterns
Lifestyle und Anti-Aging-Medizin.
T. Rabe & T. Strowitzki (Hrsg.) Rendezvous, Baden-Baden 12 (2002)

Ch. MarschallH.-G. Klein.
Analyzing Gene Expression:
Established and new ways to analyze gene expression at the mRNA and protein levels – potentialities and pitfalls.
S. Lorkowski, P. Cullen (Hrsg.), Wiley-VHC-Verlag (2002)

H.-D. Rott, B. Lemcke, M. Zenker, W. Huk, J. Horst, K. Mayer.
Cyst-like cerebral lesions in tuberous sclerosis.
Am J Med Genet. 111: 435 ( 2002)

Ch. MarschallH.-G. Klein.
Analyzing Gene Expression: Established and new ways to analyze gene expression at the mRNA and protein levels – potentialities and pitfalls.
S. Lorkowski, P. Cullen (Hrsg.), Wiley-VHC-Verlag (2002)

H.-G. Klein, U. Grau.
Arzneimittelnebenwirkungen vermeiden: Möglichkeiten der pharmako-genetischen Diagnostik.
J Lab Med. 11/12:477 (2001)

W. Höppner, H.-G. Klein, A. Ruppert.
Die massenspektrometrische DNA-Analyse für die humane Diagnostik.
J Lab Med. 11/12: 463 (2001)

A.K. Birnberger, H.-G. Klein.
Mus musculus chymotrypsin-like protease (Ctra1) gene, exons 1 through 7.
NCBI, Acc. No. AF274232 (2000)

K. Mayer, W. Ballhausen, W. Leistner, H.-D. Rott.
Three novel types of splicing aberrations in the tuberous sclerosis TSC2 gene caused by mutations apart from splice consensus sequences.
Biochem Biophys Acta 1502: 495 (2000)

J. Hass, K. Mayer, H.-D. Rott.
Tuberous sclerosis type 1: Three novel mutations detected in exon 15 by a combination of HDA and TGGE.
Hum Mutat. 16: 88 (2000)

K. Mayer, W. Ballhausen, H.-D. Rott .
Mutation screening of the entire coding regions of the TSC1 and the TSC2 gene with the protein truncation test (PTT) identifies frequent splicing defects.
Hum Mutat. 14: 401 (1999)

C. Marschall, E. Lengyel, T. Nobutoh, E. Braungart, K. Douwes, A. Simon, V. Magdolen, U. Reuning, K. Degitz. UVB increases urokinase-type plasminogen activator receptor (uPAR) expression.
J Invest Dermatol. 113(1):69 (1999)

K. Mayer, H.-D. Rott. Molekulargenetische Diagnostik bei tuberöser Sklerose (TSC): Erfahrungen mit dem Protein Truncation Test (PTT).
Medgen 10: 27 (1998)

H.-D. Rott, K. Mayer. Klinik und Genetik der tuberösen Sklerose.
Pädiat Prax. 56: 233 (1998)

C. Marschall, M. Kreimer, D. Weichart, A. Kolb, R. Hengge-Aronis.
Molecular analysis of the regulation of csiD, a carbon starvation-inducible gene in Escherichia coli that is exclusively dependent on sigma s and requires activation by cAMP-CRP.
J Mol Biol. 276(2):339 (1998)

H.-G. Klein.
Genetische Prädisposition für Tumorerkrankungen.
mta 13:76 (1998)

C. Detter, H. Mair, H.-G. Klein, C. Georgescu, A. Welz, B Reichart.
Long-term prognosis of surgically-treated aortic aneurysms and dissections in patients with and without Marfan syndrome.
Eur J Cardiothorac Surg. 13:416 (1998)

G. Collod-Béroud, C. Béroud, L. Ades, C. Black, M. Boxer, D.J. Brock, K.J. Holman, A. de Paepe, U. Francke, U. Grau, C. Hayward, H.-G. Klein, W. Liu, L. Nuytinck, L. Peltonen, A.B. Alvarez Perez, T. Rantamäki, C. Junien, C. Boileau.
Marfan Database (third edition): new mutations and new routines for the software.
Nuc Acids Res. 26:229 (1998)

U. Grau, H.-G. Klein, C. Detter, H. Mair, A. Welz, D. Seidel, B Reichart.
A novel mutation in the neonatal region of the fibrillin (FBN) 1 gene associated with a classical phenotype of Marfan Syndrome (MfS).
Hum Mut 12:137 (1998)

A. Burger-Kentischer, E. Müller, H.-G. Klein, A. Schober, W. Neuhofer, F.X. Beck.
Cationic amino acid transporter mRNA expression in rat kidney and liver.
Kidney Int Suppl. 67, 54:136 (1998)

K. Mayer, T. Hieronymus, J. Castrop, H. Clevers, W. Ballhausen.
Ectopic activation of lymphoid high mobility group-box transcription factor TCF-1 and overexpression in colorectal cancer cells.
Int J Cancer 72: 625 (1997)

A. Muffler, M. Barth, C. Marschall, R. Hengge-Aronis.
Heat shock regulation of _s turnover and the relationship between the stress responses mediated by _s and _32 in Escherichia coli.
J Bacteriol 179:445 (1997)

K. Mayer, W. Ballhausen.
Expression of alternatively spliced lck transcripts from the proximal promoter in colorectal cancer derived cell lines.
Anticancer Res. 16: 1733 (1996)

H.-G. Klein.
Die Bedeutung der molekularen Genetik in der Medizin.
Der Bay Int. 15:50(1996)

M. Barth, C. Marschall, A. Muffler, D. Fischer, R. Hengge-Aronis.
Role for the Histone-Like Protein H-NS in Growth Phase-Dependent and Osmotic Regulation of _s and Many _s-Dependent Genes in Escherichia coli.
J Bacteriol. 177:3455 (1995)

C. Marschall
, R. Hengge-Aronis.
Regulatory characteristics and promotor analysis of csiE, a stationary phase-inducible gene under the control of _s and cAMP-CRP complex in Escherichia coli.
Mol Microbiol. 18:175 (1995)

K. Mayer, E. Wolff, H. Clevers, W. Ballhausen.
The human high mobility group (HMG)-box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA.
Biochim Biophys Acta 1263: 169 (1995)

B. Vaismann, H.-G. Klein, M. Rouis, A. Berard, M.R. Kindt, G.D. Talley, S.M. Meyn, R.F. Hoyt Jr., S.M. Marcovina, J.J. Albers, J.M. Hoeg, H.B. Brewer Jr., S. Santamarina-Fojo.
Overexpression of human lecithin-cholesterol acyltransferase leads to hyperalphalipo-proteinemia in transgenic mice.
J  Biol Chem. 270:12269 (1995)

H.-G. Klein, N. Duverger, J.J. Albers, S. Marcovina, H.B. Brewer Jr., S. Santamarina-Fojo.
In vitro expression of structural defects in the lecithin-cholesterol acyltransferase (LCAT) gene.
J Biol Chem. 270: 9443 (1995)

H.-G. Klein
, S. Santamarina-Fojo, N. Duverger, M. Clerc, M.F. Dumas, J.J. Albers, S. Marcovina, H.B. Brewer Jr.
Fish Eye Syndrome: A molecular defect in the lecithin-cholesterol acyltransferase (LCAT) gene associated with normal a-LCAT specific activity - Implications for classification and prognosis.
J Clin Invest. 92:479 (1993)

C. Marschall
, P. Frenzel, H. Cypionka.
Influence of oxygen on sulfate reduction and growth of sulfate-reducing bacteria.
Arch Microbiol. 159:168  (1993)
 
H.-G. Klein
, P. Lohse, N. Duverger, J.J. Albers, D.J. Rader, L.A. Zech, S. Santamarina-Fojo, H.B. Brewer Jr.
Two different allelic mutations in the lecithin-cholesterol acyltransferase (LCAT) gene resulting in classic LCAT deficiency: LCAT (Tyr83->Stop) and LCAT (Tyr156-> Asn).
J Lipid Res 34:49 (1993)

K. Mayer
 , I. Ansotegui, W. Ballhausen.
The human lck cDNA clone YT16 is a transforming oncogene.
Anticancer Res. 12: 485 (1992)

H.-G. Klein, P. Lohse, P.H. Pritchard, D. Bojanovski, H. Schmidt, H.B. Brewer Jr.
Two different allelic mutations in the lecithin-cholesterol acyltransferase (LCAT) gene associated with the Fish Eye Syndrome. Lecithin-cholesterol acyltransferase (Thr123->Ile) and lecithin-cholesterol acyltransferase (Thr347->Met).
J Clin Invest. 89:499  (1992)

R.P. Linke, H.-G. Klein, S. Modrow, M. Marin-Grez.
Isolated atrial amyloid deposits. Immunochemical evidence for the presence of polypeptide with molecular weightshigher and lower than atrial natriuretic peptide (ANP).
J B Navig (Hrsg.), Amyloid and Amyloidosis, S. 466 (1991)

 

Publikationen unserer Mitarbeiter aus dem Bereich Zytogenetik

 

Schell-Apacik C, Cohen M, Vojta S, Klopocki E, Ullmann R, Ertl-Wagner B, Heinrich U, von Voss H. 
Gomez-Lopez-Hernandez syndrome – description of a new case and review of the literature.
Med Genetik 1: (2006)

Weimer, J., Cohen, M., Wiedemann, U., Heinrich, U., Jonat, W., Arnold, N.
Proof of partial imbalances 6q an 11q due to maternal complex balanced translocation analyzed by microdissection of multi colour labelled chromosomes (FISH-MD) in a patient with Dandy-Walker variant.
CytogenetGenome Res 114: 235 (2006)

Heinrich, U., Locher, M. und Wagner, A.
Klassische und molekulare Zytogenetik.
Thiemann, F., Cullen, P. M. und Klein, H.(Hrsg): Leitfaden Molekulare Diagnostik, S. 197. WILEY-VCH Verlag, Weinheim, (2006)

K. Mayer and C. Marschall.
Molekulargenetische Diagnostik von Bindegewebserkrankungen.
J Lab Med. 29:176 (2005)

C. Walczak, U. Heinrich, O. Beringer, H. Enders.
UPD 15 and CPM for trisomy 15: PWS due to increased maternal age.
Med Genetik 1 (1999)

U. Pesch, I. Chudoba, U. Heinrich, C. Backsch, K. Meister, D. Krüger, H. Enders
Characterization of a der(Y) chromosome by microdissection and reverse painting.
Med Genetik 1 (1999)

K. Meister, I. Chudoba, U. Heinrich, C. Backsch, U. Pesch, U. Mau, H. Enders, P. Kaiser
Application of micro-FISH to characterize an ESAC and a pericentric inversion.
Med Genetik 1 (1999)

U. Heinrich, C. Backsch, A. Mannikainen, C. Frymire, U. Klein-Vogler, H. Enders, P. Kaise
Discrepant short term and long term culture results after CVS.
Med Genetik 1 (1998)

L.Lehmann, H. Zitzelsberger, A. M. Kellerer, H. Braselmann, U. Kulka, V. Georgiadou-Schumacher, T. Negele, F. Spelsberg, E. Demidchik, E. Lengfelder, M. Bauchinger.
Chromosome translocations in thyroid tissues from Belarussian children exposed to radioiodine from the Chernobyl accident, measured by FISH-painting.
Int J Radiat Biol, Vol. 70(5):513 (1996)

K. Salassidis, V. Georgiadou-Schumacher, H. Braselmann, P. Muller, R. U. Peter, M. Bauchinger.
Cromosome painting in highly irradiated Chernobyl victims: a follow-up study to evaluate the stability of symmetrical translokations and the influence of clonal aberrations for retrospective dose estimation.
Int J Radiat Biol, Vol. 68(3): 257 (1996)

M. Bauchinger, H. Braselmann, U. Kulka, R. Huber, V. Georgiadou-Schumacher.
Quantification of FISH-painted chromosome aberrations after domestic radon exposure.
Int J Radiat Biol, Vol. 70(6): 657 (1996)

U. Heinrich, U. Klein-Vogler, C. Backsch, M. Schliephacke, M. Schneider, H. Enders, E. Wiest, P. Kaiser
Demonstration of a der(11) and a der(12) chromosome, respectively, in two related persons as a consequence of a familial translocation t(11;12) by cytogenetic analysis and FISH.
Med Genetik 2 (1995)

U. Heinrich, M. Leipoldt
Cytogenetic analysis of 15 cases of uterine leiomyomas.
Abstracts der 4. Tagung der Gesellschaft für Humangenetik (1992)

 

Publikationen unserer Mitarbeiter im Bereich Reproduktionsgenetik

 

Heinrich, U., Locher, M. und Wagner, A.
Klassische und molekulare Zytogenetik.
Thiemann, F., Cullen, P. M. und Klein, H.(Hrsg): Leitfaden Molekulare Diagnostik, S. 197-213. WILEY-VCH Verlag, Weinheim  (2006)

Wagner A, Wiedemann U, Klein H-G, Würfel W, Gagsteiger F.
Möglichkeiten und Grenzen der Polkörperdiagnostik.
Bioforum-Zellbiologie 4l: 23 (2004)

Bartsch O, Nemeckova M, Kocarek E, Wagner A, Puchmajerova A, Poppe M, Ounap K, Goetz P 
DiGeorge/velocardiofacial syndrome: FISH studies of chromosomes 22q11 and 10p14, and clinical reports on the proximal 22q11 deletion
Am J Med Genet 117(1):1 (2003)

Bartsch O, Locher K, Meinecke P, Kress W, Seemanová E, Wagner A, Ostermann K, Rödel G
Molecular studies in 10 cases of Rubinstein-Taybi syndrom, including a mild variant showing a missense mutation in codon 1175 of CREBBP
J Med Genet 39 (7): 496 (2002)

Bartsch O, Wagner A, Hinkel GK, Krebs S, Stumm M, Schmalenberger B, Böhm S, Balci S, Majewski F
FISH studies in 45 patients with Rubinstein-Taybi syndrome: deletions associated with polysplenia, hypoplastic left heart, renal agenesis and death in infancy
Eur J Hum Genet 7:748 (1999)

Bartsch O, Kreß W,  Wagner A, Seemanová E
The novel contiguous gene syndrome of myotubular myopathy (MTM1), male hypogonadism and deletion in Xq28: report of the first family. Cytogenet Cell
Genet 85: 310 (1999)

Bartsch O, Wagner A, Hinkel GK, Lichtner P, Murken J, Schuffenhauer S
No evidence for chromosomal microdeletions at the second DiGeorge syndrom locus on 10p (letter)
Am J Med Genet 83: 425 (1999)

 

Publikationen unserer Mitarbeiter aus dem Bereich Immungenetik

 

Hirv K, Bloch K, Fischer M, Einsiedler B, Schrezenmeier H, Mytilineos J.
Prediction of duration and success rate of unrelated hematopoietic stem cell donor searches based on the patient's HLA-DRB1 allele and DRB1-DQB1 haplotype frequencies.
Bone Marrow Transplant. 44(7): 433 (2009)

Hinrichs J, Figueiredo C, Hirv K, Mytilineos J, Blasczyk R, Horn PA, Eiz-Vesper B.
Discrimination of HLA null and low expression alleles by cytokine-induced secretion of recombinant soluble HLA.
Mol Immunol 46(7):1451 (2009)

Hirv K, Pannicke U, Mytilineos J, Schwarz K.
Disulfide bridge disruption in the ?2 domain of the HLA class I molecule leads to low expression of the corresponding antigen.
Hum Immunol 67:589 (2006)

Stachel DK, Leipold A, Kuhlen M, Gravou-Apostolatou C, Hirv K, Bader P, Niemeyer CM, Beck JD, Holter W.
Simultaneos control of third-degree graft-versus-host disease and prevention of recurrence of juvenile myelomonocytic leukemia (JMML) with 6-mercaptopurine following fulminant JMML relapse early after KIR-mismatched bone marrow transplantation.
J Pediatr Hematol Oncol 27:672 (2005)

K. HoelschI. Lenggeler, W. Pfannes, H. Knabe, H.-G. KleinA. Wölpl.
Routine HLA-B genotyping with PCR-sequence-specific oligonucleotides detects a B*52 variant (B*5206).
Tissue Antigens. 65(5): 488 (2005)

K. Witter, A. Wölpl, R. Zahn, H.-G. Klein, E.D. Albert.
Sequence-based typing confirmed a novel B*40 allele, B*4046, which was identified through sequence-specific oligonucleotide hybridization routine typing.
Tissue Antigens 63(4):378 (2004)

Eichler, H., Wölpl, A., Goldmann, S.F.
Sample identification errors in cord blood banking.
Tissue Antigens 57: 91 (2001)
 
Eichler, H., Wölpl, A., Schwarz, K., Richter, E., Goldmann, S.F.
Sample identification errors observed within a study for molecular cord blood HLA typing.
Infusion Therapy and Transfusion Medicine 27: 16 (2000)

Arndt, SO., Vogt, AB., Markovic-Plese, S., Martin, R., Moldenhauer, G., Wölpl, A., Sun, Y., Schadendorf, D., Hämmerling, GJ., Kropshofer, H.
Functional HLA-DM on the surface of B cells and immature dendritic cells.
Embo Journal 19, 1241 (2000)

Elsner, H.-A., Wölpl, A., Goldmann, S. F., Blasczyk, R.
Identification of the novel allele HLA-B* 1546 which belongs to the serological B72 type: implications for bone marrow transplantation
Tissue Antigens 55: 83 (2000)

Hirv K, Seyfarth M, Uibo R, Kull K, Salupere R, Latza U, Rink L.
Polymorphisms in tumour necrosis factor and adhesion molecule genes in patients with inflammatory bowel disease: associations with HLA-DR and --DQ alleles and subclinical markers.
Scand J Gastroenterol 34: 1025 (1999)

Schwarz, K., Wölpl, A., Spegel, J., Mueller, C., Goldmann, S. F.
Caucasian German Normal HLA 1998
Am Soc f Histocompatibility a Immunogen Lenexa, Kansas, USA. 149 (1998)

Eichler, H., Richter, E., Schwarz, K., Woelpl, A., Goldmann, S. F.
Turkish Normal HLA 1998
American Society for Histocompatibility and Immunogenetics Lenexa, Kansas, USAS. 190 (1998)

Eichler, H., Richter, E., Schwarz, K., Woelpl, A., Goldmann, S. F.
Caucasian German Normal HLA 1998
American Society for Histocompatibility and Immunogenetics Lenexa, Kansas, USA 150 (1998)

Löffler, D., Welschof, M., Goldmann, S. F., Wölpl, A.
Recognition of HLA-DR1/DRB1*0101 molecules presenting HLA-A2 derived peptides by a human recombinant antibody, Fab-5A1.
Europ Journal of Immunogenetics 25: 339 (1998)

Wölpl, A., Halden,T., Kalbacher, H., Neumeyer, H., Siemoneit, K., Goldmann, S. F., Eiermann, Th.
Human monoclonal antibody with T-cell-like specifity recognizes MHC class I self-peptide presented by HLA-DR1 on activated cells.
Tissue Antigens 51: 258 (1998)

Wagner, F., Simoneit, K., Wölpl, A., Flegel.
Humaner monoklonaler Antikörper gegen enzymbehandelte Erythrozyten.
Infusionsther Transfusionsmed. Basel, Karger, 33: 40 (1996)

Schreiner, Th., Prochnow-Calzia, H., Maccari, B., Erne, E., Kinzler, I., Wölpl, A., Wiesneth, M.
Chimerism analysis after allogenic bone marrow transplantation with nonradioactive RFLP and PCR-AFLP using the same DNA.
Journal of Immunological Methods, 196: 93 (1996)
 
Wölpl, A., Toubert, A., Siemoneit, K., Eiermann, Th., Neumayer H., Goldmann, S. F.
Characterization of two human IgM monoclonal antibodies reactive with HLA-B27.
Tissue Antigens 46; 305 (1995)
 
Siemoneit, K., Cardoso, M., Koerner, K., Wölpl, A., Kubanek.
Human monoclonal antibodies for the immunological characterization of a highly conserved protein domain of the hepatitis C virus glycoprotein E1.
Clin Exp Immunol. 101: 278 (1995)

Driessen C, Hirv K, Wellinghausen N, Kirchner H, Rink L.
Influence of serum on zinc, toxic shock syndrome toxin-1, and lipopolysaccharide-induced production of IFN-gamma and IL-1 beta by human mononuclear cells.
J Leukoc Biol 57:904 (1995)

Driessen C, Hirv K, Kirchner H, Rink L.
Divergent effects of zinc on different bacterial pathogenic agents.
J Infect Dis 171: 486 (1995)

Driessen C, Hirv K, Kirchner H, Rink L.
Zinc regulates cytokine induction by superantigens and lipopolysaccharide.
Immunology 84: 272 (1995)

Driessen C, Hirv K, Rink L, Kirchner H.
Induction of cytokines by zinc ioins in human peripheral blood mononuclear cells and separated monocytes.
Lymphokine Cytokine Res 13:15 ( 1994)

Siemoneit, K., Cardoso, M., Wölpl, A., Epple, S., Wintersinger, H., Koerner, K., Kubanek, K.
Isotype-specific immune response to a sigle hepatits C virus core epitope defined by a human monoclonal antibody: diagnostic value and correlation to PCR.
Ann Hematol. 69: 129  (1994)

Wölpl, A., Fischer, M., Eiermann, Th., Goldmann, S. F.
Vergleich der HLA-Typisierungs- und Retypisierungsdaten bei Patienten mit Knochenmarktransplantation.
Infusionsther. Transfusionsmed. 32: 266 (1994)

Siemoneit, K., Cardoso, M., Wölpl, A., Koerner, K., Kubanek,.K.
Isolation and epitope characterization of human monoclonal antibodies to Hepatitis C virus core antigen.
Hybridoma 13: 9 (1994)

Siemoneit, K., Wölpl, A., Wegener, S., Ernst, M., Sonneborn, H.-H., Goldmann, S. F.
Generation and characterization of a human monoclonal IgG antibody specific for HLA-B12.
Tissue Antigens 44: 25 (1994)

Eiermann, Th., Ballas, M., Fakler, J., Müller, C., Wölpl, A., Goldmann, S. F.
Selection of unrelated bone marrow donors: Does the current procedure warrant complete MHC class II identity?
Infusionsther. 30: 320 (1992)

Knobloch, C., Wölpl, A., Ballas, M., Friedrich, W., Goldmann, S. F.
HLA class II recognition of T cells differentiated in HLA semiallogeneic environment following bone marrow transplantation for severe combined immunodeficiency.
HLA 1991, Vol. II (Editors: Tsuji, K., Aizawaam M., Sasazuki, T.), Oxford University Press, Oxford, New York, Tokyo; 449 (1992)

Eiermann, Th., Ballas, M., Fakler, J., Wölpl, A., Goldmann, S. F.
Selection of unrelated marrow donors: Does the current procedure warrant complete MHC class II identity?
Infusionstherapie 19:127 (1992)

Ballas, M., Eiermann, Th., Wölpl, A., Goldmann, S. F.
Mapping of an HLA-DRw52-associated determinant on DRb1 molecules.
Tissue Antigens 36: 187 (1990)

Goldmann, S. F., Eiermann, Th., Wölpl, A., Ballas, M.
Mapping of an HLA-DRw52 associated determinant on DRb1 molecules.
Visuals of the Clinical Histocompatibility Workshop  One Lambda Inc., Los Angeles; 194 (1990)

Goldmann, S. F., Ballas, M., Eiermann, Th., Wölpl, A.
Discrimination capacity of class II RFLP patterns in unrelated HLA-A, B, DR identical patient donor combinations.
Visuals of the Clinical Histocompatibility Workshop  One Lambda Inc., Los Angeles; 88 (1990)

Eiermann, Th., Winkelmann, S., Ballas, M., Wölpl, A., Goldmann, S. F.
Alloreactive T-cell clones raised in an HLA-B/D crossing over family dissect HLA-DR5 and HLA-DQw3 subtypes.
Human Immunology 29: 117 (1990)

Wölpl, A., Ballas, M., Eiermann, Th., Martin, R., Grosse-Wilde, H., Goldmann, S. F.
DRw15 associated MLC heterozygousity confirmed by RFLP typing.
European Histocompatibility conference, Council of Europe, Strasbourg; 190 (1990)

Ballas, M., Wölpl, A., Eiermann, Th., Knobloch, C., Goldmann, S. F.
HLA-Class II typing by RFLP and protein chemistry reveal discrepances relevant in unrelates donor bone marrow transplantation.
European Histocompatibility Conference, Council of Europe, Strasbourg; 86 (1990)

Eiermann, Th., Winkelmann, S., Ballas, M., Wölpl, A., Goldmann, S. F.
Alloreactive T cell clones raised in an HLA-B/D crossing over family dissect HLA-DR5 and HLA-DQw3 subtypes.
European Histocompatibility Conference, Council of Europe, Strasbourg; 28 (1990)

Ballas, M., Eiermann, Th., Wölpl, A., Goldmann, S. F.
The allelic determinants HLA-DR3 and HLA-DR5 and the supertypic determinant HLA-DRw52 may be located on the same DRb chain.
Immunbiology of HLA, Vol. II Springer Verlag New York, 263 (1989)

Eiermann, Th., Wölpl, A., Ballas, M., Heinz, W., Arnold, R., Heit, W., Goldmann, S. F.
Risk factors for GvhD and Graft Rejection in Bone Marrow Transplantation from HLA identical siblings.
Bone Marrow Transplantation 4 (Suppl. 2): 116 (1989)

Eiermann, Th., Krause, S., Wölpl, A., Ballas, M., Goldmann, S. F.
Monoclonal antibody to a supertypic determinant associated with HLA-DRw52.
Hybridoma 8: 467 (1989)

Steuer, M., Mauff, G., Adam, C., Baur, M. P., Bender, K., Goetz, J., Goldmann, S. F., Hauptmann, G., Neugebauer, M., Tongio, M. M., Uring-Lambert, B., Wölpl, A.
An estimate on the frequency of duplicated haplotypes and silent alleles of hum C4 protein polymorphism. I. Investigation in healthy Caucasoid families.
Tissue Antigens 33: 501 (1989)

A. Wölpl, Goldmann, S. F., Eiermann, Th., Arnold, R.
Die Bedeutung der Klasse III und GLO-Allele bei der Auswahl von HLA-identischen Knochenmarkspendern.
Beiträge zur Infusionstherapie und klinische Ernährung (Hrsg.: Kretschmar, V., Stangel, W.), Karger Verlag, Basel 18: 326 (1987)

Goldmann, S. F., Ebell, W., Blütters-Sawatzki, R., Eiermann, Th., Kreth, W., Wölpl, A., Friedrich, W.
Graft versus Host Reaktion (GvHR) nach perinataler maternofetaler Transfusion bzw. nach Substitution mit Blutzellen: Der diagnostische Wert der HLA-Testung.
Beiträge zur Infusionstherapie und klinische Ernährung (Hrsg.: Kretschmar, V., Stangel, W.), Karger Verlag, Basel 18: 321 (1987)

Goldmann, S. F., Wölpl, A., Eiermann, Th.
Erfahrungen bei der Suche eines histokompatiblen Knochenmarkspenders in der Familie und in der nichtverwandten Bevölkerung
Beiträge zur Infusionstherapie und klinische Ernährung (Hrsg.: Kretschmar, V., Stangel, W.), Karger Verlag, Basel 18: 305 (1987)

Eiermann, Th., Raghachavar, A., Wölpl, A., Ballas, M., Fischer, M., Goldmann, S. F.
Generation and characterization of three new monoclonal antibodies detecting the allospecifities HLA-A2, w69, HLA-A3 and HLA-B13.
Tissue Antigens 29: 201 (1987)

A. Wölpl, Goldmann, S. F., Eiermann, Th., Arnold, R.
Discrimination value of class III and glyoxalase alleles for selection of histocompatible bone marrow donors.
Transplantation Proceedings 19: 2632 (1987)

Eiermann, Th., Martin, A., Wölpl, A., Goldmann, S. F.
Evidence for a lymphocyte activation determinant coded by the HLA-region different from HLA-DR, DQ and DP.
Transplantation Proceedings 19: 866 (1987)

Wölpl, A., Lattke, H., Board, P. G., Arnold, R., Schmeiser, T., Kubanek, B., Robin-Winn, M., Pichlmayr, R., Goldmann, S. F.
Coagulation factor XIII A and B subunits in bone marrow and liver transplantation.
Transplantation 43: 151 (1987)

Wölpl, A., Lattke, H., Arnold, R., Schmeiser, T., Kubanek, B., Robin-Winn, M., Pichlmayr, R., Goldmann, S. F.
Site of synthesis of different molecules can be detected after organ transplantation.
Transplantation Proceedings 18: 1343 (1986)

Wölpl, A., Robin-Winn, M., Pichlmayr, R., Goldmann, S. F.
Fourth component of complement (C4) polymorphism in human orthotopic liver transplantation.
Transplantation 40: 154 (1985)

Northoff, H., Wölpl, A., Brewersdorf, H., Faulhaber, JD.
An ABO-Blood group abnormality leading to the detection of a Colon-Carcinoma.
Blut 46:161 (1983)

Wölpl, A., Goldmann, S. F.
Definition of three monocyte specific antigens with human alloantisera.
Transplantation Proceedings 15: 232 (1983)

 

Publikationen unserer Mitarbeiter aus dem Bereich Pharmakogenetik

 

H.-G. Klein,  B.Busse,
Pharmacogenetics in Laboratory Diagnostics
Current Pharmacogenomics & Personalized Medicine 6(1) (2008)

F. Rückerl, B. Busse, J. Bachl,
Episomal vectors to monitor and induce somatic hypermutation in human Burkitt-Lymphoma cell lines
Molecular Immunology 43:1645 ( 2006)

B. BusseH.-G. Klein.
Pharmakogenetik – Der differenzierte Blick auf die Patienten
Biologen heute 2 (2005)

B. Busse, H.G. Klein,
Pharmakogenetik: Chancen für bessere  Pharmakokinetik
Biologen heute 2 (2005)

B. Busse,
Genetisch bedingte Nebenwirkungen vermeiden
Deutsches Ärzteblatt/Praxis Computer 2 (2004)

B. Busse, U. Grau, H.-G. Klein,
Pharmakogenetik:  Ermittlung der individuellen Effektivität von Arzneimitteln und Vermeidung von Nebenwirkungen
MTA Dialog (2004)

B. Busse,
Pharmakogenetik: Der DrugProfiler hilft, Medikamente individuell zu dosieren
Trillium-Report 2(2): 12 (2004)

H.-G. Klein, J. Rauch, B. Busse, U. Grau, C. Marschall, 
Single Nucleotide Polymorphisms in der medizinischen Prädispositionsdiagnostik
Der Frauenarzt 44:1 (2003)

 

Publikationen unserer Mitarbeiter aus dem Bereich Onkologie

 

Würfel W, Klein HG, Wagner AHinrichsen T.
Genetisches Spiegelbild der Eizelle: Den Polkörper diagnostisch nutzen.
Ärztliche Praxis; Gynäkologie 12 (2008)

Heuser M, Argiropoulos B, Kuchenbauer F, Yung E, Piper J, Fung S, Schlenk RF, Dohner K, Hinrichsen T, Rudolph C, Schambach A, Baum C, Schlegelberger B, Dohner H, Ganser A, Humphries RK.
MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML.
Blood. 10 (5):1639 (2006)

Heinrich ULocher M und Wagner A
Klassische und molekulare Zytogenetik.
Thiemann F, Cullen PM und Klein H(Hrsg): Leitfaden Molekulare Diagnostik, S. 197 WILEY-VCH Verlag, Weinheim (2006)

Steinemann D, Skawran B, Becker T, Tauscher M, Weigmann A, Wingen L, Tauscher S,Hinrichsen T, Hertz S, Flemming P, Flik J, Wiese B, Kreipe H, Lichter P, Schlegelberger B, Wilkens L.
Assessment of differentiation and progression of hepatic tumors using array-based comparative genomic hybridization.
Clin Gastroenterol Hepatol. 4(10): 1283. (2006)

K. Mayer, T. Hieronymus, J. Castrop, H. Clevers, W. Ballhausen.
Ectopic activation of lymphoid high mobility group-box transcription factor TCF-1 and overexpression in colorectal cancer cells.
Int J Cancer 72: 625 (1997)

K. Mayer, W. Ballhausen.
Expression of alternatively spliced lck transcripts from the proximal promoter in colorectal cancer derived cell lines.
Anticancer Res. 16: 1733 (1996)

K. Mayer , I. Ansotegui, W. Ballhausen.
The human lck cDNA clone YT16 is a transforming oncogene.
Anticancer Res. 12: 485 (1992)